简介：Interferon-based or judicious use of NA in compensated disease, appropriate rescue for drug resistance; continue NA(s) till after 6M HBeAg seroconversion (HBeAg+ CHB), HBsAg clearance (HBeAg – CHB).Protracted severe acute hepatitis B (INR increase and deep jaundice > 4M) treat with lamivudine, telbivudine or entecavir till HBsAg clearance or indefinite if OLT.